Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat.
作者： Kyoji Yamada , Keisuke Yoshitake , Masaki Sato , Dennis J. Ahnen
DOI: 10.1016/0016-5085(92)91109-H
关键词:
摘要: Abstract Expression of the proliferating cell nuclear antigen (PCNA) was examined in normal rat intestinal tissues and carcinogen-treated nonneoplastic neoplastic colonic mucosa. In intestine, PCNA expression confined to expected region proliferative compartment. A strong correlation observed between labeling index both [ 3 H]thymidine ( R = 0.993, P 0.007) percent cells S phase as determined by flow cytometry 0.982, 0.018) location maximal staining for 0.997,
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