Palliative pamidronate treatment in patients with bone metastases from breast cancer.
作者： A T van Holten-Verzantvoort , H M Kroon , O L Bijvoet , F J Cleton , L V Beex
DOI: 10.1200/JCO.1993.11.3.491
关键词:
摘要: PURPOSEAn open, randomized study was performed to assess the effects of supportive pamidronate treatment on morbidity from bone metastases in breast cancer patients.PATIENTS AND METHODSEighty-one patients and 80 control were monitored for a median 18 21 months, respectively, events skeletal radiologic course metastatic disease. The oral dose 600 mg/d (high [HD]) during earliest years, then changed 300 (low [LD]) because gastrointestinal toxicity. Twenty-nine 81 (HD/LD) first received mg/d; 52 LD throughout study. Tumor unrestricted.RESULTSAn overall intent-to-treat analysis performed. In group, occurrence hypercalcemia, severe pain, symptomatic impending fractures decreased by 65%, 30%, 50%, respectively; event-rates systemic treatmen...
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