Medical Laser-Induced Thermotherapy - Models and Applications

摘要: Heat has long been utilised as a therapeutic tool in medicine. Laser-induced thermotherapy aims at achieving the local destruction of lesions, relying on conversion light absorbed by tissue into heat. In interstitial laser-induced thermotherapy, is focused thin optical fibres, which are placed deep tumour mass. The objective this work was to increase understanding physical and biological phenomena governing response with special reference treatment liver tumours benign prostatic hyperplasia. Mathematical models were used calculate distribution absorption subsequent temperature laser-irradiated tissues. investigate influence number different factors, such design laser probe, properties tissue, duration irradiation, blood perfusion boundary conditions. New results concerning transurethral microwave obtained incorporating microwaves model. Prototypes new applicators for anatomically correct hyperplasia developed tested ex vivo. Experimental pointed importance eliminating flow during reduce convective heat loss. addition, it shown that hepatic inflow occlusion increased thermal sensitivity tissue. dynamic investigated using Doppler flowmetry. Vessel damage after combined photodynamic therapy studied. (Less)