Lobophytones U - Z1, Biscembranoids from the Chinese Soft Coral Lobophytum pauciflorum
作者： Pengcheng Yan , Zhiwei Deng , Leen van Ofwegen , Peter Proksch , Wenhan Lin
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摘要: Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation seven new biscembranoids named lobophytones U–Z1 (1–7, resp.), together with methyl sartortuoate (8) and nyalolide (9). The structures compounds were elucidated by 1D- 2D-NMR (COSY, HSQC, HMBC, NOESY) spectroscopic analysis association MS IR data. All tested against lipopolysaccharide (LPS)-induced nitric oxide (NO) release mouse peritoneal macrophage. Lobophytone Z (6) inhibited NO production an IC50 value 2.6 μM. H (1) showed inhibitory activities bacteria S. aureus pneumoniae.
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