Cytotoxic and Antibacterial Cembranoids from a South China Sea Soft Coral, Lobophytum sp.
作者： Min Zhao , Jian Yin , Wei Jiang , Minshan Ma , Xinxiang Lei
DOI: 10.3390/MD11041162
关键词: Staphylococcus aureus 、 Microbiology 、 Cytotoxic T cell 、 Antibacterial activity 、 Coral 、 South china 、 Anthozoa 、 Bacteria 、 Lobophytum 、 Biology
摘要: Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*, 4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E, 11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*, 3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4-14. The structures compounds were elucidated through extensive spectroscopic analysis, including 1D 2D NMR data. Compounds 1-3 exhibited moderate cytotoxic activity against selected tumor cell lines. Moreover, 2 3 found be inhibitors bacteria S. aureus pneumoniae.
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