Association analysis between the C516T polymorphism in the 5-HT2A receptor gene and schizophrenia.
作者： Vivian Bertola , Quirino Cordeiro , Stevin Zung , Elisabete Cristina Miracca , Homero Vallada
DOI: 10.1590/S0004-282X2007000100004
关键词:
摘要: Data from epidemiological studies have demonstrated that genetics is an important risk factor for schizophrenia. Disturbances of serotonergic brain pathways been implicated in the pathophysiology Some suggested efficacy atypical antipsychotics on schizophrenia treatment may be related to serotonin 2A receptor (5-HT2A), and drugs induce psychotic symptoms. Thus, aim this study was investigate association between C516T polymorphism a Brazilian population composed by 246 patients 315 healthy matched controls case-control approach. No statistically differences were observed allelic (c2=1.77, 1d.f., p=0.18) or genotypic (c2=1.69, 2d.f., p=0.42) distributions cases controls. The results suggest 5-HT2A gene not susceptibility our sample.
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