Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease
作者： Quirino Cordeiro , Ricardo Noguti , Cássio Bottino , Homero Vallada , None
DOI: 10.1590/S0004-282X2010000200007
关键词:
摘要: Several genes have been related to late-onset Alzheimer's disease (LOAD). Phospholipases A2 (PLA2) influence the processing and secretion of amyloid precursor protein, which gives rise beta-amyloid peptide, major component plaque in AD. Hence, present study, polymorphisms three encoding PLA2 enzymes group (cytosolic PLA2: BanI cPLA2 polymorphism; calcium-independent AvrII iPLA2 PAFAH: Val279Phe PAFAH polymorphism) were analysed a case-control sample using 58 patients with LOAD 107 matched healthy controls. There was genotypic association between polymorphism (chi2=6.25, 2df, p=0.04), however there no allelic association. associations LOAD. These data suggest that may play role susceptibility for our Brazilian sample.
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