Association between BanI genotype and increased phospholipase A2 activity in schizophrenia
作者： Nadia R Barbosa , Ricardo M Junqueira , Homero P Vallada , Wagner F Gattaz , None
DOI: 10.1007/S00406-007-0736-0
关键词:
摘要: Phospholipases A2 (PLA2) are a family of key enzymes in the metabolism membrane phospholipids. Several studies reported on increased blood and brain PLA2 activity schizophrenia, which suggest disordered phospholipid disease. In addition, genetic variant cytosolic gene has been to be associated with schizophrenia. These data indicate that variants encoding genes plausible candidates for increasing susceptibility this study, we investigated possible association between platelets polymorphic site BanI (group 4A) chromosome 1q25. Seventy-five schizophrenic patients (DSM-IV) 68 healthy controls were recruited PCR assays performed. A radioenzymatic assay was used. The allele genotype A2A2 more frequent than (p < 0.005 p 0.05 respectively). When assorted subjects according their genotypes, found significantly higher (29.6 ± 5.1 pMol/mg protein/min) those A1A2 (20.8 3.6 protein/min, 0.001) or A1A1 (15.9 0.001). Also controls, carriers (A1A2 A2A2) had group = 0.004 both). Our an PLA2G4A presence may increase risk schizophrenia through increment activity.
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