Clinical, Immunological, and Virological Outcomes Among Youths With Perinatal HIV After Transition to Adult Units in Spain From 1997 to 2016.
作者： David Aguilera-Alonso , Talía Sainz , Santiago Jimenez de Ory , Ignacio Bernardino , Cristina Díez
DOI: 10.1097/QAI.0000000000002539
关键词:
摘要: Background Children living with HIV are reaching adulthood and transitioning to adult clinics. This study aimed describe clinical immunovirological status after transition in patients perinatal HIV. Methods Patients participating the Spanish multicenter pediatric cohort (CoRISpe) transferred care (FARO cohort) from 1997 2016 were included. Clinical data collected 12 years old last follow-up moment (up December 2017). We used mixed-effect models analyze changes CD4 counts or viral suppression multivariate analysis for risk factors virological failure (VF) immune transition. Transition classified into five-year periods. Results 332 youths Median age at was 18 (IQR: 16.3-18.9), 58.1% women. time 6.6 4.6-9.8) 11 (3.3%) died. Immunovirological improved over Globally, VF decreased 27.7% 14.4% 3 post-transition (p Conclusions After early periods, immunological remained stable. Nevertheless, some had higher of worse outcomes. Identifying these may aid during
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