Virological and Social Outcomes of HIV-Infected Adolescents and Young Adults in The Netherlands Before and After Transition to Adult Care

摘要: Background. As a result of effective combination antiretroviral therapy (cART) and advanced supportive healthcare, growing number human immunodeficiency virus (HIV)-infected children survive into adulthood. The period transition to adult care is often associated with impaired adherence treatment discontinuity care. We aimed evaluate virological social outcomes HIV-infected adolescents young adults (AYAs) before after transition, explore which factors are failure. Methods. included 59 AYAs from the Netherlands who had entered pediatric transitioned healthcare. used HIV RNA load cART data Dutch Stichting Monitoring database (1996-2014), collected patients' medical records all centers 14 involved. evaluated risk for failure (VF) in logistic regression model adjusted repeated measurements. Results. VF occurred frequently during study (14%-36%). During (from 18 19 years age) there was significant increase compared reference group aged 12-13 (odds ratio, 4.26 [95% confidence interval, 1.12-16.28]; P =. 03). Characteristics significantly were low educational attainment lack autonomy regarding medication at transition. Conclusions. vulnerable VF, especially period. Identification high might help improve success this group.