Growing up with perinatal HIV: changes in clinical outcomes before and after transfer to adult care in the UK.
作者： Ali Judd , Intira Jeannie Collins , Francesca Parrott , Teresa Hill , Sophie Jose
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摘要: Introduction : With improved survival, adolescents with perinatal HIV (PHIV) are transitioning from paediatric to adult care, but there few published data on clinical outcomes post-transfer. Using linked patients in the national UK/Ireland cohort (CHIPS) and an UK of outpatient clinics (UK CHIC), we describe mortality changes immunological status Methods Participants CHIPS aged ≥13 years by end 2013 were CHIC database. Mixed effects models explored CD4 count before after transfer, including interactions between time variables where interaction p 400 copies/mL or one viral load >10,000 copies/mL, likewise 102 (52%) 12 months post-transfer ( = 0.79). Seven (3%) people died care. In multivariable analysis, declined as approached transition a greater decline those higher nadir (mean rates 3, 13, 15, 30 cells/mm 3 per year for < 100, 100–199, 200–299 ≥300 , respectively). Post-transition, continued some groups (e.g. black males, −20 (−34, −5) post transition, 0.007)) while it others. Overall was later birth (14 (7, 21) year). There no effect age at transfer changing hospital CD4. Conclusions Our findings suggest that declining period reversal this trend groups. Across period, years, suggesting improvements care and/or planning over time. Keywords adolescent; young person; perinatal; HIV; United Kingdom; transition; transfer; care; (Published: 16 May 2017) Judd A et al. Journal International AIDS Society 2017, 20(suppl 3) :21577 http://www.jiasociety.org/index.php/jias/article/view/21577 | http://dx.doi.org/10.7448/IAS.20.4.21577
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jiasociety.org 参考文章(37)
Renee Smith, Miriam Chernoff, Paige L. Williams, Kathleen M. Malee, Patricia A. Sirois, Betsy Kammerer, Megan Wilkins, Sharon Nichols, Claude Mellins, Ann Usitalo, Patricia Garvie, Richard Rutstein, Impact of HIV severity on cognitive and adaptive functioning during childhood and adolescence. Pediatric Infectious Disease Journal. ,vol. 31, pp. 592- 598 ,(2012) , 10.1097/INF.0B013E318253844B
R Fish, A Judd, E Jungmann, C O'Leary, C Foster, , Mortality in perinatally HIV‐infected young people in England following transition to adult care: an HIV Young Persons Network (HYPNet) audit Hiv Medicine. ,vol. 15, pp. 239- 244 ,(2014) , 10.1111/HIV.12091
S Jose, K Quinn, D Dunn, A Cox, C Sabin, S Fidler, UK CHIC and UK HDRD Steering Committees, Jonathan Ainsworth, Sris Allan, Jane Anderson, Abdel Babiker, David Chadwick, Valerie Delpech, Martin Fisher, Brian Gazzard, Richard Gilson, Mark Gompels, Phillip Hay, Teresa Hill, Margaret Johnson, Stephen Kegg, Clifford Leen, Fabiola Martin, Mark Nelson, Chloe Orkin, Adrian Palfreeman, Andrew Phillips, Deenan Pillay, Frank Post, Jillian Pritchard, Memory Sachikonye, Achim Schwenk, Anjum Tariq, John Walsh, Alicia Thornton, Adam Glabay, N Perry, S Tilbury, E Youssef, D Churchill, R Everett, D Asboe, S Mandalia, H Korat, C Taylor, Z Gleisner, F Ibrahim, L Campbell, N Brima, I Williams, M Youle, F Lampe, C Smith, R Tsintas, C Chaloner, S Hutchinson, S Huntington, N Mackie, A Winston, J Weber, F Ramzan, M Carder, J Lynch, J Hand, C Souza, S Munshi, S Miller, C Wood, A Wilson, S Morris, S Allan, A Palfreeman, K Memon, A ewszuk, D Chadwick, E Cope, J Gibson, S Kegg, P Main, Dr Mitchell, Dr Hunter, P Hay, M Dhillon, F Martin, S Russell‐Sharpe, A Harte, S Clay, A Tariq, H Spencer, R Jones, C Atkinson, V Delpech, M Sachikonye, Celia Aitken, Anton Pozniak, Patricia Cane, Duncan Clark, Simon Collins, Samuel Douthwaite, Ellen White, Christophe Fraser, Anna Maria Geretti, Antony Hale, Stéphane Hué, Steve Kaye, Paul Kellam, Linda Lazarus, Andrew Leigh‐Brown, Tamyo Mbisa, Samuel Moses, Eleni Nastouli, Erasmus Smit, Kate Templeton, Peter Tilston, Daniel Webster, Hongyi Zhang, Jane Greatorex, Jane Mullen, Richard Tandy, Tracy Fawcett, Mark Hopkins, Lynn Ashton, Claire Booth, Ana Garcia‐Diaz, Jill Shepherd, Matthias L Schmid, Brendan Payne, Spiro Pere, Jonathan Hubb, Stuart Kirk, Rory Gunson, Amanda Bradley‐Stewart, None, Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation Hiv Medicine. ,vol. 17, pp. 368- 372 ,(2016) , 10.1111/HIV.12302
Debra S Lotstein, Michael Seid, Georgeanna Klingensmith, Doug Case, Jean M Lawrence, Catherine Pihoker, Dana Dabelea, Elizabeth J Mayer-Davis, Lisa K Gilliam, Sarah Corathers, Giuseppina Imperatore, Lawrence Dolan, Andrea Anderson, Ronny A Bell, Beth Waitzfelder, SEARCH for Diabetes in Youth Study Group, None, Transition From Pediatric to Adult Care for Youth Diagnosed With Type 1 Diabetes in Adolescence Pediatrics. ,vol. 131, ,(2013) , 10.1542/PEDS.2012-1450
Michael T Brady, James M Oleske, Paige L Williams, Carol Elgie, Lynne M Mofenson, Wayne M Dankner, Russell B Van Dyke, Pediatric AIDS Clinical Trials Group219/219C Team, Declines in mortality rates and changes in causes of death in HIV-1-infected children during the HAART era. Journal of Acquired Immune Deficiency Syndromes. ,vol. 53, pp. 86- 94 ,(2010) , 10.1097/QAI.0B013E3181B9869F
Mweete D Nglazi, Katharina Kranzer, Pearl Holele, Richard Kaplan, Daniella Mark, Heather Jaspan, Stephen D Lawn, Robin Wood, Linda-Gail Bekker, Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa. BMC Infectious Diseases. ,vol. 12, pp. 21- 21 ,(2012) , 10.1186/1471-2334-12-21
Patrick A Ryscavage, Evan J Anderson, Sarah H Sutton, Susheel Reddy, Babafemi Taiwo, Clinical outcomes of adolescents and young adults in adult HIV care Journal of Acquired Immune Deficiency Syndromes. ,vol. 58, pp. 193- 197 ,(2011) , 10.1097/QAI.0B013E31822D7564
Shoshana Y. Kahana, Maria Isabel Fernandez, Patrick A. Wilson, Jose A. Bauermeister, Sonia Lee, Craig M. Wilson, Lisa B. Hightow-Weidman, Rates and correlates of antiretroviral therapy use and virologic suppression among perinatally and behaviorally HIV-infected youth linked to care in the United States. Journal of Acquired Immune Deficiency Syndromes. ,vol. 68, pp. 169- 177 ,(2015) , 10.1097/QAI.0000000000000408
Brian C. Zanoni, Kenneth H. Mayer, The Adolescent and Young Adult HIV Cascade of Care in the United States: Exaggerated Health Disparities Aids Patient Care and Stds. ,vol. 28, pp. 128- 135 ,(2014) , 10.1089/APC.2013.0345
Sarah M Wood, Samir S Shah, Andrew P Steenhoff, Richard M Rutstein, The impact of AIDS diagnoses on long-term neurocognitive and psychiatric outcomes of surviving adolescents with perinatally acquired HIV. AIDS. ,vol. 23, pp. 1859- 1865 ,(2009) , 10.1097/QAD.0B013E32832D924F