Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration.
作者： Guy C. Brown , Juan P. Bolaños , Simon J.R. Heales , John B. Clark
DOI: 10.1016/0304-3940(95)11703-Y
关键词:
摘要: Cultured astrocytes, activated to express the inducible form of nitric oxide synthase, produced up 1 μM (NO) measured by a NO-selective electrode, while non-activated cells no detectable NO. The production NO was associated with an inhibition cellular respiration, simultaneously oxygen electrode. respiration rapidly reversed inhibiting synthase or binding haemoglobin. respiratory had NO, and substrate dependence consistent NO-inhibition at cytochrome oxidase. This is first demonstration that can reversibly inhibit mitochondrial via production. large potentially important in range pathophysiological conditions.
elsevier.com
sci-hub.se 参考文章(13)
M.W.J. Cleeter, J.M. Cooper, V.M. Darley-Usmar, S. Moncada, A.H.V. Schapira, Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide FEBS Letters. ,vol. 345, pp. 50- 54 ,(1994) , 10.1016/0014-5793(94)00424-2
Thomas E. Lane, Jean E. Merrill, Louis J. Ignarro, Michael P. Sherman, Judy Melinek, Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. Journal of Immunology. ,vol. 151, pp. 2132- 2141 ,(1993)
Carl Nathan, Nitric oxide as a secretory product of mammalian cells. The FASEB Journal. ,vol. 6, pp. 3051- 3064 ,(1992) , 10.1096/FASEBJ.6.12.1381691
Steven R. Vincent, Nitric oxide: A radical neurotransmitter in the central nervous system Progress in Neurobiology. ,vol. 42, pp. 129- 160 ,(1994) , 10.1016/0301-0082(94)90023-X
M. Schweizer, C. Richter, Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension Biochemical and Biophysical Research Communications. ,vol. 204, pp. 169- 175 ,(1994) , 10.1006/BBRC.1994.2441
D. S. Bredt, S. H. Snyder, V. L. Dawson, T. M. Dawson, E. D. London, Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 6368- 6371 ,(1991) , 10.1073/PNAS.88.14.6368
Sean Murphy, Martha L. Simmons, Luis Agullo, Agustina Garcia, Douglas L. Feinstein, Elena Galea, Donald J. Reis, Dahlia Minc-Golomb, Joan P. Schwartz, Synthesis of nitric oxide in CNS glial cells. Trends in Neurosciences. ,vol. 16, pp. 323- 328 ,(1993) , 10.1016/0166-2236(93)90109-Y
Jean E. Merrill, Macroglia: neural cells responsive to lymphokines and growth factors. Immunology Today. ,vol. 8, pp. 146- 150 ,(1987) , 10.1016/0167-5699(87)90144-7
Guy C. Brown, Chris.E. Cooper, Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase FEBS Letters. ,vol. 356, pp. 295- 298 ,(1994) , 10.1016/0014-5793(94)01290-3
Stuart A. Lipton, Yun-Beom Choi, Zhuo-Hua Pan, Sizheng Z. Lei, Huei-Sheng Vincent Chen, Nikolaus J. Sucher, Joseph Loscalzo, David J. Singel, Jonathan S. Stamler, A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds Nature. ,vol. 364, pp. 626- 632 ,(1993) , 10.1038/364626A0