Mass spectrometric approaches for the investigation of dynamic processes in condensed phase

摘要: Mass spectrometry (MS) offers many advantages over other established spectroscopic techniques employed for the investigation of processes in condensed phase. The sensitivity, specificity, and speed afforded by MS-based methods enable to obtain very valuable insights into mechanism complex dynamic processes. Off-line rely on quenching halt progress reaction interest allow implementation a broad range analytical procedures sample fractionation, isolation, or desalting. On contrary, on-line are designed carry out real-time monitoring through continuous uninterrupted analysis mixtures, with only caveat that solutions be directly amenable available ionization technique. utilization rapid mixing devices direct connection mass spectrometer included off-line schemes provides access initial moments reaction, which can offer important information about mechanism. This report summarizes different off- strategies developed study chemical biochemical reactions solution kinetic/mechanistic information. merits various experimental designs, characteristics instrumental setups, factors affecting time resolution discussed aid specific examples, highlight contributions MS facets