APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis
作者： John Maciejowski , Aikaterini Chatzipli , Alexandra Dananberg , Titia de Lange , Peter J. Campbell
DOI: 10.1101/725366
关键词:
摘要: Chromothripsis and kataegis are frequently observed in cancer can arise from telomere crisis, a period of genome instability during tumorigenesis when depletion the reserve generates unstable dicentric chromosomes1–5. Here we report on mechanism underlying chromothripsis using an vitro crisis model. We show that cytoplasmic exonuclease TREX1, which promotes resolution chromosomes4, plays prominent role chromothriptic fragmentation. In absence alterations induced by primarily involve Breakage-Fusion-Bridge cycles simple rearrangements rather than chromothripsis. Furthermore, at breakpoints is consequence cytosine deamination APOBEC3B. addition, APOBEC3B increased frequency fragmentation, possibly due to strand breakage after deamination. These data reveal combination nucleolytic processing TREX1 editing
sci-hub.st 参考文章(31)
Karl Lenhard Rudolph, Melissa Millard, Marcus W. Bosenberg, Ronald A. DePinho, Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nature Genetics. ,vol. 28, pp. 155- 159 ,(2001) , 10.1038/88871
Natalia Tretyakova, Jason B. Nikas, Douglas Yee, Nuri A. Temiz, Duncan E. Donohue, Rebecca M. McDougle, William L. Brown, Emily K. Law, Reuben S. Harris, Michael B. Burns, Lela Lackey, Michael A. Carpenter, Anurag Rathore, Allison M. Land, Brandon Leonard, Eric W. Refsland, Delshanee Kotandeniya, APOBEC3B is an enzymatic source of mutation in breast cancer Nature. ,vol. 494, pp. 366- 370 ,(2013) , 10.1038/NATURE11881
Steven A Roberts, Michael S Lawrence, Leszek J Klimczak, Sara A Grimm, David Fargo, Petar Stojanov, Adam Kiezun, Gregory V Kryukov, Scott L Carter, Gordon Saksena, Shawn Harris, Ruchir R Shah, Michael A Resnick, Gad Getz, Dmitry A Gordenin, An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nature Genetics. ,vol. 45, pp. 970- 976 ,(2013) , 10.1038/NG.2702
P. Van Loo, S. H. Nordgard, O. C. Lingjaerde, H. G. Russnes, I. H. Rye, W. Sun, V. J. Weigman, P. Marynen, A. Zetterberg, B. Naume, C. M. Perou, A.-L. Borresen-Dale, V. N. Kristensen, Allele-specific copy number analysis of tumors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 16910- 16915 ,(2010) , 10.1073/PNAS.1009843107
Eric W. Refsland, Mark D. Stenglein, Keisuke Shindo, John S. Albin, William L. Brown, Reuben S. Harris, Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction Nucleic Acids Research. ,vol. 38, pp. 4274- 4284 ,(2010) , 10.1093/NAR/GKQ174
B KAVLI, M OTTERLEI, G SLUPPHAUG, H KROKAN, Uracil in DNA--general mutagen, but normal intermediate in acquired immunity. DNA Repair. ,vol. 6, pp. 505- 516 ,(2007) , 10.1016/J.DNAREP.2006.10.014
Peter J. Campbell, Telomeres and cancer: from crisis to stability to crisis to stability. Cell. ,vol. 148, pp. 633- 635 ,(2012) , 10.1016/J.CELL.2012.01.043
Steven A. Roberts, Joan Sterling, Cole Thompson, Shawn Harris, Deepak Mav, Ruchir Shah, Leszek J. Klimczak, Gregory V. Kryukov, Ewa Malc, Piotr A. Mieczkowski, Michael A. Resnick, Dmitry A. Gordenin, Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions Molecular Cell. ,vol. 46, pp. 424- 435 ,(2012) , 10.1016/J.MOLCEL.2012.03.030
Yilong Li, Claire Schwab, Sarra L. Ryan, Elli Papaemmanuil, Hazel M. Robinson, Patricia Jacobs, Anthony V. Moorman, Sara Dyer, Julian Borrow, Mike Griffiths, Nyla A. Heerema, Andrew J. Carroll, Polly Talley, Nick Bown, Nick Telford, Fiona M. Ross, Lorraine Gaunt, Richard J. Q. McNally, Bryan D. Young, Paul Sinclair, Vikki Rand, Manuel R. Teixeira, Olivia Joseph, Ben Robinson, Mark Maddison, Nicole Dastugue, Peter Vandenberghe, Claudia Haferlach, Philip J. Stephens, Jiqiu Cheng, Peter Van Loo, Michael R. Stratton, Peter J. Campbell, Christine J. Harrison, Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia Nature. ,vol. 508, pp. 98- 102 ,(2014) , 10.1038/NATURE13115
Bas van Steensel, Agata Smogorzewska, Titia de Lange, TRF2 Protects Human Telomeres from End-to-End Fusions Cell. ,vol. 92, pp. 401- 413 ,(1998) , 10.1016/S0092-8674(00)80932-0