Hypermutation in single-stranded DNA
作者： Natalie Saini , Dmitry A. Gordenin
DOI: 10.1016/J.DNAREP.2020.102868
关键词:
摘要: Regions of genomic DNA can become single-stranded in the course normal replication and transcription as well during repair. Abnormal repair intermediates contain large stretches persistent DNA, which is extremely vulnerable to damaging agents hypermutation. Since such spans only a fraction genome at given instance, hypermutation these regions leads tightly-spaced mutation clusters. This phenomenon has been documented several experimental models cancer genomes. Recently, hypermutated RNA viral genomes also have documented. Moreover, indications may be found human germline. review will summarize key current knowledge recent developments understanding diverse mechanisms sources ssDNA
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