Lipid–Polymer Nanoparticles Encapsulating Doxorubicin and 2′-Deoxy-5-azacytidine Enhance the Sensitivity of Cancer Cells to Chemical Therapeutics

作者: Xianwei Su , Zhaohui Wang , Lili Li , Mingbin Zheng , Cuifang Zheng

DOI: 10.1021/MP300675C

关键词:

摘要: Nanomedcine holds great potential in cancer therapy due to its flexibility on drug delivery, protection, releasing, and targeting. Epigenetic drugs, such as 2′-deoxy-5-azacytidine (DAC)…

参考文章(36)
Jane A. Plumb, Julieann Sludden, Robert Brown, Stanley B. Kaye, Gordon Strathdee, Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Research. ,vol. 60, pp. 6039- 6044 ,(2000)
Chantal Rigal, Jennifer Perez, Raphaël Rousseau, Christine Bardin, Besse Anthony, Aurelie Dutour, Anti-MDR1 siRNA Restores Chemosensitivity in Chemoresistant Breast Carcinoma and Osteosarcoma Cell Lines Anticancer Research. ,vol. 31, pp. 2813- 2820 ,(2011)
Guo-Hua Qiu, Manuel Salto-Tellez, James A. Ross, Winnie Yeo, Yan Cui, Nicholas Wheelhouse, George G. Chen, David Harrison, Paul Lai, Qian Tao, Shing Chuan Hooi, The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle Journal of Hepatology. ,vol. 48, pp. 433- 441 ,(2008) , 10.1016/J.JHEP.2007.11.015
Pawan K. Singal, Natasha Iliskovic, Doxorubicin-Induced Cardiomyopathy The New England Journal of Medicine. ,vol. 339, pp. 900- 905 ,(1998) , 10.1056/NEJM199809243391307
Cuifang Zheng, Mingbin Zheng, Ping Gong, Dongxue Jia, Pengfei Zhang, Bihua Shi, Zonghai Sheng, Yifan Ma, Lintao Cai, Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging. Biomaterials. ,vol. 33, pp. 5603- 5609 ,(2012) , 10.1016/J.BIOMATERIALS.2012.04.044
T J Seng, J S W Low, H Li, Y Cui, H K Goh, M L Y Wong, G Srivastava, D Sidransky, J Califano, R D M Steenbergen, S Y Rha, J Tan, W-S Hsieh, R F Ambinder, X Lin, A T C Chan, Q Tao, The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene. ,vol. 26, pp. 934- 944 ,(2007) , 10.1038/SJ.ONC.1209839
Donghao Shang, Yuting Liu, Qingjun Liu, Fengbo Zhang, Lang Feng, Wencheng Lv, Ye Tian, Synergy of 5-aza-2′-deoxycytidine (DAC) and paclitaxel in both androgen-dependent and -independent prostate cancer cell lines Cancer Letters. ,vol. 278, pp. 82- 87 ,(2009) , 10.1016/J.CANLET.2008.12.034