Expression profile of N-cadherin differs from other classical cadherins as a prognostic marker in renal cell carcinoma.

摘要: Renal cell carcinomas (RCCs) primarily express cadherin-6 and N-cadherin rather than E-cadherin, the aberrant expression of correlates with a poor prognosis in patients E-cadherin-absent RCC. However, role RCC has not yet been elucidated. In this study, we analyze pattern surgical specimens discuss function together re-evaluation our previous study. Forty-six surgically resected were used The localization E-cadherin demonstrated by immunohistochemistry. Correlations between each cadherin, pathological parameters patient survival analyzed. expressed as normal despite elevation tumor grade, N-cadherin-normal had poorer those N-cadherin-abnormal Since study showed that only functioned attachment when impaired, plays different from or may be associated aggressiveness malignant potential