Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response

摘要: Psoriasis is a chronic inflammatory skin disease in which Th17 cells play crucial role. Since indigenous gut microbiota influences the development and reactivity of immune cells, we analyzed link among microbiota, T formation psoriatic lesions imiquimod-induced murine model psoriasis. To explore role induced inflammation germ-free (GF), broad-spectrum antibiotic (ATB)-treated or conventional (CV) BALB/c C57BL/6 mice. We found that both mice reared GF conditions for several generations CV treated with ATB were more resistant to than The treatment dramatically changed diversity bacteria, remained stable after subsequent imiquimod application; resulted substantial increase order Lactobacillales significant decrease Coriobacteriales Clostridiales. Moreover, as compared mice, lower degree local systemic activation ATB-treated These findings suggest control by altering cell response.