AN INVESTIGATION INTO THE ANTI-DIARRHEAL PROPERTY OF MONTELEUKAST

摘要: Diarrhea is an increase in the frequency, fluidity or volume of bowel movements. refers to frequent defecation liquid feces. It caused by increased motility and decreased absorption intestines. When chyme passes too quickly through large intestine, there not enough time left for absorption. can result dehydration electrolyte imbalance. Monteleukast a leukotriene antagonist used treatment Asthma. An excess secretion leukotrienes prostaglandins our gastrointestinal tract results diarrhea.This antagonizing property monteleukast has been exploited present investigation determine whether any antidiarrheal property.This study was undertaken evaluate effect dose 10 mg/kg using magnesium sulphate induced diarrhea model. found that therapeutic showed significant reduction stools which might be due to, inhibition synthesis are responsible diarrhea. administered at reduced total weight feaces 4 hrs, (11.0g±1.2**) number wet feces hrs. (10.0g ±1.4**). This compared control group (16.0g ± 0.56 15.0g 0.98). Also more mean percentage 31.25% as group. While loperamide 2 54.37% These suggest possesses efficacy may its antimotility antisecretory actions.