The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures

摘要: Numerous analyses of large patient cohorts identified specific patterns immune activation associated with survival. We established these as the contexture , encompassing type, functional orientation, density, and location adaptive cells within distinct tumor regions. Based on contexture, a standardized, powerful stratification system, Immunoscore was delineated. The is characterized by signatures also observed in association broader phenomenon immune-mediated, tissue-specific destruction. defined immunologic constant rejection . Predictive, prognostic, mechanistic overlap, continuum intratumor reactions exists. balance between cell growth elimination may be tipped upon crescendo induced manipulations aimed at enhancing naturally occurring immunosurveillance. Here, we propose immunological interpretation three concepts—immune Immunoscore, rejection—that segregates oncogenic processes independently their tissue origin.