Reactivity of non-primate growth hormones and prolactins with human growth hormone receptors on cultured human lymphocytes.

摘要: Ovine placental lactogen is as reactive human growth hormone with the receptor of cultured (IM-9) lymphocytes, which confirms findings Carr and Friesen receptors liver. We now also show that bovine ovine hormones prolactin have reactivity for on IM-9 lymphocytes same order magnitude (0.03%) previously reported lactogen. The binding studies predict these non-primate will biological effects skeletal in primates, either agonists or antagonists. Previous shown when are exposed to 18 h at 37 C, there a time concentration dependent loss receptors, after preincubation C greater than average occupancy under steady state conditions 90 min 30 C. In present s...