Gene sequence screening for manganese poisoning-susceptible genes and analysis of gene interaction effects.
作者： Yutian Tian , Shuhan Guo , Cengceng Chen , Li Zhao , Zhen Li
DOI: 10.1016/J.ETAP.2018.09.013
关键词:
摘要: Manganese poisoning is a common occupational disease, studies have found that the susceptibility to manganese differs in individuals. We adopted genome-wide sequencing methods screen for genes involved gene-mediated metabolic pathways from perspective of poisoning. identified 18,439 this study, including 14,272 known and 4398 new genes. then selected 17 differential using p values, which 7 were down-regulated 10 up-regulated. Possible interaction each gene according String database. Sgk1, HCRTr1, HspB1, Rem2, Oprd1, ATF5, TRHr study may be oxidative stress mechanisms, dopamine (DA) synthesis, neuronal survival during apoptosis affect
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