Contributions of the epidermal growth factor receptor to keratinocyte motility.
作者： Laurie G. Hudson , Lisa J. McCawley
DOI: 10.1002/(SICI)1097-0029(19981201)43:5<444::AID-JEMT10>3.0.CO;2-C
关键词:
摘要: The epidermal growth factor (EGF) receptor plays a central role in numerous aspects of keratinocyte biology. In normal epidermis, the EGF is important for autocrine this renewing tissue, suppression terminal differentiation, promotion cell survival, and regulation migration during morphogenesis wound healing. wounded skin, transiently up-regulated an contributor to proliferative migratory reepithelialization. keratinocytic carcinomas, aberrant expression or activation common has been proposed play tumor progression. Many cellular processes such as altered adhesion, matrix degrading proteinases, are keratinocytes healing metastatic tumors. able regulate each these functions we propose that transient dynamic elevation healing, constitutive overexpression tumors, provides contribution invasive potential keratinocytes.
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