High mortality risk of prostate cancer patients in Asia and West Africa: A systematic review.

摘要: Globally, prostate cancer (PCa) is the second most preponderant in men. It contributes to high mortality-to-incidence ratio reported West Africa and Asia largely due low screening. The mortality risk determined or predicted based on prevalence of high-risk aggressive PCa using a scoring grading system such as Gleason score (GS), grade (GG), prostate-specific antigen (PSA) level. In this review, peer-reviewed articles found databases Google Scholar, Scopus, Web Science, PubMed Central and, EMBASE were selected adherence clinical guidelines for classification PCa. Asia, result revealed that frequency was 42% 51.2% GS, 48.8% 25.3% GG pattern, 87.5% 44.3% PSA level >10 ng/mL, respectively. Data both when compared with developed countries. However, higher than Asia. Studies have shown PCas are associated germline mutations prevalent blacks Asians whites. Thus, testing patients GS ≥ 7, 3, density, volume, levels >4.0 ng/mL may identify those at developing lethal could reduce rates Africa.