Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40.

摘要: Polyomavirus family consists of a highly diverse group small DNA viruses. The founding member (MPyV) was first discovered in the newborn mouse late 1950s, which induces solid tumors wide variety tissue types that are epithelial and mesenchymal origin. Later, other members were also isolated from number mammalian, avian fish species. Some these viruses significantly contributed to our current understanding fundamentals modern biology such as transcription, replication, splicing, RNA editing, cell transformation. After discovery two human polyomaviruses (JC virus [JCV] BK [BKV]) early 1970s, there has been rapid expansion recent years due availability new technologies brought present 14. cause considerably serious diseases, including progressive multifocal leukoencephalopathy, polyomavirus-associated nephropathy, Merkel carcinoma, trichodysplasia spinulosa. Emerging evidence suggests expression polyomavirus genome is more complex than previously thought. In addition encoding universally expressed regulatory structural proteins (LT-Ag, Sm t-Ag, VP1, VP2, VP3), some express additional virus-specific microRNAs. This review summarizes advances with respect viral microRNAs ones. addition, special emphasis devoted functional discoveries field agnoprotein only by JCV, BKV, simian 40 genomes.