Alzheimer - Parkinson Disease Spectrum and Diffuse Lewy Body Disease

摘要: Diffuse Lewy body disease (DLBD) is a recently recognized primary degenerative dementia that shares pathological features with Alzheimer's (AD) and Parkinson's (PD) (5,6,10–13,16). Clinically, it difficult to diagnose DLBD (2) most patients come autopsy diagnosis of AD or less commonly progressive supranuclear palsy (5), because rigidity axial dystonia in some patients, CreutzfeldtJacob disease, myoclonus periodic complexes on electroencephalograms (18). In the majority subjects, cognitive decline overshadows motor abnormalities. Despite degeneration substantia nigra diencephalon indistinguishable from PD, have had no apparent extrapyramidal features.