Fatal Combined Infection With Canine Distemper Virus and Orthopoxvirus in a Group of Asian Marmots (Marmota caudata)

摘要: A fatal combined infection with canine distemper virus (CDV) and orthopoxvirus (OPXV) in Asian marmots (Marmota caudata) is reported this article. total of 7 from a small zoological garden Switzerland were found dead hibernation during routine check the winter 2011. The died February No clinical signs disease observed at any time. viruses detected all individuals for which tissues available (n = 3). Detection was performed by reverse transcription polymerase chain reaction. most consistent gross lesion neck thorax edema. necrotizing pharyngitis multifocal pneumonia histologically. Numerous large intracytoplasmic eosinophilic inclusions seen epithelial cells pharynx, airways, skin keratinocytes. Brain lesions limited to mild gliosis. Phylogenetic analysis revealed that marmot CDV strain closely related clusters CDVs wild carnivores local outbreak 2002 2009-2010 nationwide epidemic, suggesting spillover wildlife. OPXV cowpoxvirus, poxvirus species considered endemic Europe. This first instance rodent infection.