Determination of mirodenafil and sildenafil in the plasma and corpus cavernous of SD male rats
作者： Sang Kyu Lee , Yoon Kim , Tae Kon Kim , Guang-Jin Im , Bong-Yong Lee
DOI: 10.1016/J.JPBA.2008.11.004
关键词:
摘要: The purpose of the present study was to determine sildenafil and a novel PDE-5 inhibitor, mirodenafil in plasma corpus cavernosum tissue rats compare their pharmacokinetic properties. concentrations rat samples were analyzed using LC-MS/MS after single oral administration at dose 40mg/kg rats. Although T(max), Tlambda(1/2) MRT not different between sildenafil, C(max) AUC significantly higher than those tissue. Consequently remained longer This may provide evidence for assessment vivo efficacy sildenafil.
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