Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated mice.
作者： A.U. N’jai , M. Larsen , L. Shi , C.R. Jefcoate , C.J. Czuprynski
DOI: 10.1016/J.TOX.2010.02.009
关键词:
摘要: In this study we used colony forming unit (CFU) assays to demonstrate rapid suppression (within 6h) of lymphoid (CFU-preB) and myeloid (CFU-GM) progenitor cells in DMBA-treated mice. The duration these changes were consistent with the blood levels DMBA its metabolites that achieved by either IP or oral administration. CFU-GM CFU-preB activities returned control 2 7 days after exposure, respectively, but remained suppressed through continued presence low bloodstream following administration was associated sustained CFU-preB, total bone marrow peripheral lymphocytes. noted above not observed Cyp1b1 null mice, demonstrating need for local metabolism impair CFU-GM. Furthermore, data provide evidence myeloid-lineage are restored more quickly than lymphoid-lineage exposure.
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