Studies on cytotoxicity and antitumor screening of red and white forms of Abrus precatorius L.

作者: R. Sivakumar , C. Alagesaboopathi

DOI: 10.4314/AJB.V7I22.59494

关键词:

摘要: The cytotoxicity study with cancer cell line A-549 indicated that the methanol insoluble fraction of crude red forms Abrus precatorius is toxic (CTC50 175,100 mg/ml) in microculture tetrazolium assay and sulphorhodamine B assays, whereas fractions white exhibited toxicity at still higher concentrations. However, an antitumor screening by short-term DLA cells showed extracts to be comparatively less toxic.

参考文章(11)
P. K. Warrier, C. Ramankutty, V. P. K. Nambiar, R. Vasudevan Nair, Indian Medicinal Plants: A Compendium of 500 Species ,(1993)
Ke Hu, Hisayoshi Kobayashi, Aijun Dong, Yongkui Jing, Shigeo Iwasaki, Xinsheng Yao, Antineoplastic Agents III: Steroidal Glycosides from Solanum nigrum Planta Medica. ,vol. 65, pp. 35- 38 ,(1999) , 10.1055/S-1999-13958
P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J. T. Warren, H. Bokesch, S. Kenney, M. R. Boyd, New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening Journal of the National Cancer Institute. ,vol. 82, pp. 1107- 1112 ,(1990) , 10.1093/JNCI/82.13.1107
Kanhoba Ranchoddas Kirtikar, Baman Das Basu, Indian Medicinal Plants ,(2018)
M. Sirsi, V. V. Subba Reddy, Effect of Abrus precatorius L. on Experimental Tumors Cancer Research. ,vol. 29, pp. 1447- 1451 ,(1969)
M.C. Unnikrishnan, Ramadasan Kuttan, Cytotoxicity of extracts of spices to cultured cells Nutrition and Cancer. ,vol. 11, pp. 251- 257 ,(1988) , 10.1080/01635588809513995
S S Rao, K Hemadri, Leucorrhoea and menorrhagia: tribal medicine. Ancient Science of Life. ,vol. 3, pp. 40- 41 ,(1983)
Shanta Mehrotra, D.N. Singh Gautam, P.N. Singh, Comparative Study of Processed (Shodhit) and Unprocessed Seeds of 'Gunja'-Abrus precatorius L. Natural product sciences. ,vol. 5, pp. 127- 133 ,(1999)
Girija Kuttan, Ramadasan Kuttan, V. Ramnath, Antitumour effect of abrin on transplanted tumours in mice. Indian journal of physiology and pharmacology. ,vol. 46, pp. 69- 77 ,(1972)