作者: M.L. Brown , M. Braun , L. Cicalese , C. Rastellini
DOI: 10.1016/J.TRANSPROCEED.2004.11.019
关键词:
摘要: Islet transplantation success is limited by the posttransplant inflammatory response, and we are investigating ability of antioxidants to neutralize this islet damage. We have shown that pyruvate can enhance engraftment functionality a suboptimal mass in rats. The present study further investigated effects pyruvate, as well vitamin E C. In A, 350 syngeneic islets were transplanted into liver chemically diabetic Antioxidant treatment, or vehicle, was administered during perioperative period an intraperitoneal glucose tolerance test (IPGTT) performed 2 months posttransplant. B, 500 under kidney capsule treatment period. Islet-bearing grafts harvested 24, 48, 96 hours for histological study. Results revealed only significantly effective enhancing mass. Respectively, 56% 80% pyruvate-treated rats became normoglycemic after A B had normal insulin response IPGTT. Histology results from islet-bearing kidneys inconclusive whether not has antiapoptotic effect. conclude but C, aids with much effectiveness full Further investigation mechanism protection still warranted.