Regulation of Immunity to Tuberculosis.

摘要: Immunity against Mycobacterium tuberculosis requires a balance between adaptive immune responses to constrain bacterial replication and the prevention of potentially damaging activation. Regulatory T (Treg) cells express transcription factor Foxp3+ constitute an essential counterbalance inflammatory Th1 are required maintain homeostasis. The first reports describing presence Foxp3-expressing CD4+ Treg in (TB) emerged 2006. Different cell subsets, most likely specialized for different tissues microenvironments, have been shown expand both human TB animal models TB. Recently, additional functional roles demonstrated during stages spectrums disease. regulatory can quickly early infection impede onset cellular immunity persist chronic infection. Increased frequencies associated with detrimental outcome active TB, may be dependent on M. strain, model, local environment, stage Some investigations also suggest that together effector obtain reduced pathology sterilizing immunity. In this review, we will provide overview mechanisms control Then, review what is known about phenotype function from studies experimental We discuss potential role progression disease relevance knowledge future efforts prevent, modulate, treat