CD4+CD25+FoxP3+ regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease
作者： Xinchun Chen , Boping Zhou , Meizhong Li , Qunyi Deng , Xueqiong Wu
DOI: 10.1016/J.CLIM.2006.11.009
关键词:
摘要: CD4(+)CD25(+) regulatory T cells (Treg) play a central role in the prevention of autoimmunity and control immune responses by down-regulating function effector CD4(+) or CD8(+) cells. The Treg Mycobacterium tuberculosis infection persistence is inadequately documented. Therefore, current study was designed to determine whether CD4(+)CD25(+)FoxP3(+) may modulate immunity against human (TB). Our results indicate that number increases blood at site active TB patients. frequency pleural fluid inversely correlates with local MTB-specific (p<0.002). These lymphocytes isolated from are capable suppressing IFN-gamma IL-10 production expanded patients suppress M. therefore contribute pathogenesis TB.
elsevier.com
sci-hub.se 参考文章(42)
M G Roncarolo, H Spits, J S Abrams, R De Waal Malefyt, R Lahesmaa, H Yssel, J E de Vries, IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. Journal of Immunology. ,vol. 149, pp. 2378- 2384 ,(1992)
Tetsuro Sasada, Motohide Kimura, Yuka Yoshida, Michiyuki Kanai, Arimichi Takabayashi, None, CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer. ,vol. 98, pp. 1089- 1099 ,(2003) , 10.1002/CNCR.11618
Shimon Sakaguchi, Noriko Sakaguchi, Misako Itoh, Masanao Asano, Masaaki Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. Journal of Immunology. ,vol. 155, pp. 1151- 1164 ,(1995)
Kevin J. Maloy, Fiona Powrie, Regulatory T cells in the control of immune pathology Nature Immunology. ,vol. 2, pp. 816- 822 ,(2001) , 10.1038/NI0901-816
Marcello Chieppa, Giancarlo Bianchi, Andrea Doni, Annalisa Del Prete, Marina Sironi, Gordana Laskarin, Paolo Monti, Lorenzo Piemonti, Andrea Biondi, Alberto Mantovani, Martino Introna, Paola Allavena, Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program The Journal of Immunology. ,vol. 171, pp. 4552- 4560 ,(2003) , 10.4049/JIMMUNOL.171.9.4552
Valerie J. Quesniaux, Delphine M. Nicolle, David Torres, Laurent Kremer, Yann Guérardel, Jérôme Nigou, Germain Puzo, François Erard, Bernhard Ryffel, Toll-Like Receptor 2 (TLR2)-Dependent-Positive and TLR2-Independent-Negative Regulation of Proinflammatory Cytokines by Mycobacterial Lipomannans Journal of Immunology. ,vol. 172, pp. 4425- 4434 ,(2004) , 10.4049/JIMMUNOL.172.7.4425
C Pirmez, P F Barnes, C L Cooper, S D Mistry, T H Rea, R L Modlin, Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis. Journal of Immunology. ,vol. 142, pp. 1114- 1119 ,(1989)
Sachi Tsunemi, Tsuyoshi Iwasaki, Takehito Imado, Satoshi Higasa, Eizo Kakishita, Takuma Shirasaka, Hajime Sano, Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients. AIDS. ,vol. 19, pp. 879- 886 ,(2005) , 10.1097/01.AIDS.0000171401.23243.56
Kripa V Jalapathy, C Prabha, Sulochana D Das, Correlates of protective immune response in tuberculous pleuritis. Fems Immunology and Medical Microbiology. ,vol. 40, pp. 139- 145 ,(2004) , 10.1016/S0928-8244(03)00303-1
Giovanna Roncador, Philip J. Brown, Lorena Maestre, Sophie Hue, Jorge L. Martínez-Torrecuadrada, Khoon-Lin Ling, Sarah Pratap, Christy Toms, Bridget C. Fox, Vincenzo Cerundolo, Fiona Powrie, Alison H. Banham, Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. European Journal of Immunology. ,vol. 35, pp. 1681- 1691 ,(2005) , 10.1002/EJI.200526189