Fibrin as a scaffold for cardiac tissue engineering.

摘要: Fibrin is a natural biopolymer with many interesting properties, such as biocompatibility, bioresorbability, ease of processing, ability to be tailored modify the conditions polymerization, and potential for incorporation both cells cell mediators. Moreover, fibrin network has nanometric fibrous structure, mimicking extracellular matrix, it can also used in autologous applications. Therefore, found applications tissue engineering, combined cells, growth factors, or drugs. Because major limitation cardiac therapy low engraftment, use biodegradable scaffolds specific homing situ retention desirable. Thus, fibrin-based injectable engineering may enhance efficacy. Fibrin-based biomaterials heart valves patches. The aim this review show bioengineering uses fibrin, delivery vehicle an implantable biomaterial.