Thickening of the Infarcted Wall by Collagen Injection Improves Left Ventricular Function in Rats: A Novel Approach to Preserve Cardiac Function After Myocardial Infarction

摘要: Objectives We determined whether collagen implantation could thicken the infarcted left ventricular (LV) wall and improve LV function. Background hypothesized that thickening by using might result in some benefits are similar to what previously had been reported when was thickened with cells. Methods Fischer rats one-week-old myocardial infarcts were injected or saline (100 μl) into scar (n = 12 each group). Six weeks later, angiograms, hemodynamics, regional blood flow assessed. The hearts processed for measurements of postmortem volume histology. Results Collagen injection significantly increased thickness (719 ± 26 μm) compared saline-treated group (440 34 μm, p 2.6 × 10−6). By angiography, stroke larger collagen-treated (163 8 than (129 6 μl, 0.005), ejection fraction also greater (48.4 1.8%) (40.7 1.0%, 0.002). Analysis motion demonstrated paradoxical systolic bulging 5 10 averaged 20.3 2.6% diastolic circumference, but none 11 (p 0.012). end-diastolic end-systolic volumes 319 μl 190 7 group, respectively. There a trend (343 23 μl), smaller (180 16 group. Conclusions This study shows thickens an infarct improves fraction, prevents after infarction.