Role of collagen in acute myocardial infarct expansion.
作者： P Whittaker , D R Boughner , R A Kloner
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摘要: BACKGROUNDWe sought to determine if damage the myocardial collagen network was cause of infarct expansion.METHODS AND RESULTSUsing polarized light microscopy, we examined sections from rat hearts obtained at 1, 2, 3, and 4 days after permanent coronary artery occlusion. Three features likely be important in resisting expansion were assessed: quality, quantity, organization. We observed a decrease number normally birefringent fibers as early 1 day infarction. This correlated significantly with time (r = -0.989, p less than 0.001). In addition, found that fewer present, greater degree (assessed by measurement total left ventricular cross-sectional area). At infarction, noted loss intermyocyte struts interstitial space. These changes coincided onset pronoun...
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