Capecitabine plus 3-weekly irinotecan (XELIRI regimen) as first-line chemotherapy for metastatic colorectal cancer: phase II trial results.
作者： Yehuda Z. Patt , Fa-Chyi Lee , James E. Liebmann , Dimitrios Diamandidis , S Gail Eckhardt
DOI: 10.1097/COC.0B013E31804B40BB
关键词:
摘要: Background: Capecitabine results in superior response rate, improved safety, and improved convenience compared with 5-fluorouracil (FU)/leucovorin (LV) in metastatic colorectal cancer (MCRC). Irinotecan in combination with 5-FU/LV has been shown to improve efficacy compared with 5-FU/LV alone in MCRC. Therefore, we evaluated the efficacy and safety of capecitabine plus irinotecan every 3 weeks (XELIRI regimen) as first-line treatment. Methods: Patients with MCRC who were< 65 years of age received irinotecan 250 mg/m 2 iv …
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