The Risk of Systemic Lupus Erythematosus Associated With Vaccines: An International Case-Control Study

摘要: Objective Studies have suggested that systemic lupus erythematosus (SLE) may be triggered by vaccinations. We undertook this study to investigate the relationship between vaccination and onset of SLE. Methods This international case–control was conducted April 2008 June 2012 in 36 specialist referral centers (34 France 2 Quebec, Canada) recruited patients ≤60 years old recently diagnosed as having either definite SLE (meeting ≥4 American College Rheumatology [ACR] criteria including at least 1 immunologic criterion) or probable 3 ACR criterion). Controls were from general practice settings through a closely monitored protocol matched age, sex, region residence, date recruitment. Vaccinations other potential risk factors for assessed using standardized telephone interview. compared proportions controls who vaccinated 12 24 months before index (date first clinical symptom presented patient) odds ratios (ORs) conditional logistic regression. Results We 105 (89 with 16 SLE) 712 controls. Twenty-two (21.0%) 181 (25.4%) had received within (adjusted OR 0.9 [95% confidence interval 0.5–1.5]). The previous also similar. Conclusion Our showed no association exposure developing SLE.