Familiality in Barrett's Esophagus, Adenocarcinoma of the Esophagus, and Adenocarcinoma of the Gastroesophageal Junction
作者： Amitabh Chak , Heather Ochs-Balcom , Gary Falk , William M. Grady , Margaret Kinnard
DOI: 10.1158/1055-9965.EPI-06-0293
关键词:
摘要: Background and Aim: The familial aggregation of Barrett's esophagus, adenocarcinoma the gastroesophageal junction, jointly termed may represent a complex genetic trait. aim this study was to determine proportion patients with these diseases who have esophagus. Methods: Information on reflux symptoms, known risk factors for family history esophagus cancers, collected at six hospitals using structured questionnaire from probands either long-segment or junction. Family esophageal cancer in first- second-degree relative determined by reviewing medical records all relatives reported be affected. Results: Seventy one 411 (17.3%) an affected and/or relative. Upon review reportedly relatives, definitively case 30 (7.3%) comprising 17 276 (6.2%) 11 116 (9.5%) 2 21 diagnosis proband found not 15 (3.6%) cases. could 26 (6.3%) cases which There were no significant differences age disease onset, gender, race, symptoms between definitive nonfamilial probands. Conclusion: Familial can confirmed 7.3% persons presenting (Cancer Epidemiol Biomarkers Prev 2006;15(9):1668–73)
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