Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma

摘要: Abstract Objectives Obesity increases the risk of developing renal cell carcinoma (RCC); however, it remains unclear whether obesity is associated with RCC aggressiveness and survival. We used data from a large cohort patients treated surgically for clear to evaluate association pathologic features tumor cancer-specific outcomes. Methods From 1988 2002, 970 underwent nephrectomy at Mayo Clinic Rochester had body mass index (BMI) available. To BMI surgery features, we chi-square Fisher's exact tests. then analyzed survival using Kaplan-Meier curves Cox regression models. Results Overweight (BMI 25 less than 30 kg/m 2 ) obese or more) were more likely present less-aggressive tumors compared normal-weight ). The 5-year rate was 62.3%, 76.9%, 81.7% normal, overweight, patients, respectively. overweight (hazard ratio 0.64, 95% confidence interval 0.49 0.84) 0.48, 0.36 0.66) reduced death in normal range. inverse attenuated after adjustment well-known predictors aggressiveness. Conclusions offers little additional prognostic information beyond accepted features; an increased disease profile presentation warrants further exploration.