S100 proteins in cancer
作者： Anne R. Bresnick , David J. Weber , Danna B. Zimmer
DOI: 10.1038/NRC3893
关键词:
摘要: In humans, the S100 protein family is composed of 21 members that exhibit a high degree structural similarity, but are not functionally interchangeable. This proteins modulates cellular responses by functioning both as intracellular Ca(2+) sensors and extracellular factors. Dysregulated expression multiple common feature human cancers, with each type cancer showing unique profile or signature. Emerging in vivo evidence indicates biology most complex multifactorial, these actively contribute to tumorigenic processes such cell proliferation, metastasis, angiogenesis immune evasion. Drug discovery efforts have identified leads for inhibiting several members, two inhibitors progressed clinical trials patients cancer. Review highlights new findings regarding role diagnosis treatment, contribution signalling tumour biology, development treating
nature.com
pubmed.cn
elsevier.com参考文章(199)
Danna B. Zimmer, Rena G. Lapidus, David J. Weber, In Vivo Screening of S100B Inhibitors for Melanoma Therapy Methods of Molecular Biology. ,vol. 963, pp. 303- 317 ,(2013) , 10.1007/978-1-62703-230-8_18
P. S. Rudland, R. Barraclough, M. P. A. Davies, F. E. M. Gibbs, B. R. Davies, Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1 Oncogene. ,vol. 8, pp. 999- 1008 ,(1993)
Lei Jiang, Yiu-Kay Lai, Jinfang Zhang, Hua Wang, Marie C M Lin, Ming-liang He, Hsiang-fu Kung, Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis Molecular Medicine. ,vol. 17, pp. 709- 716 ,(2011) , 10.2119/MOLMED.2011.00008
Baldwin A, Chaplin J, Rast M, Zimmer Db, S100-mediated signal transduction in the nervous system and neurological diseases. Cellular and Molecular Biology. ,vol. 51, pp. 201- ,(2005)
Guoyou Zhang, Jing Jin, Yushu Bai, Ming Li, Changwei Yang, Knockdown of S100A4 decreases tumorigenesis and metastasis in osteosarcoma cells by repression of matrix metalloproteinase-9. Asian Pacific Journal of Cancer Prevention. ,vol. 12, pp. 2075- 2080 ,(2011)
Ulrike Stein, Franziska Arlt, Janice Smith, Ulrike Sack, Pia Herrmann, Wolfgang Walther, Margit Lemm, Iduna Fichtner, Robert H. Shoemaker, Peter M. Schlag, Intervening in β-Catenin Signaling by Sulindac Inhibits S100A4-Dependent Colon Cancer Metastasis Neoplasia. ,vol. 13, pp. 131- 144 ,(2011) , 10.1593/NEO.101172
N.S. Ambartsumian, M.V. Kriajevska, M.S. Grigorian, G.P. Georgiev, E.M. Lukanidin, M.N. Cardenas, Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 gene Journal of Biological Chemistry. ,vol. 269, pp. 19679- 19682 ,(1994) , 10.1016/S0021-9258(17)32072-0
Sina Grebhardt, Karin Müller-Decker, Felix Bestvater, Michal Hershfinkel, Doris Mayer, Impact of S100A8/A9 expression on prostate cancer progression in vitro and in vivo. Journal of Cellular Physiology. ,vol. 229, pp. 661- 671 ,(2014) , 10.1002/JCP.24489
Ethan D. Emberley, Yulian Niu, Leigh C. Murphy, Ladislav Tomes, Peter H. Watson, R. Daniel Gietz, Etienne Leygue, Psoriasin Interacts with Jab1 and Influences Breast Cancer Progression Cancer Research. ,vol. 63, pp. 1954- 1961 ,(2003)
Angela Platt-Higgins, John H. R. Winstanley, Philip S. Rudland, Roger Barraclough, Christopher R. West, Christine Renshaw, Lynne Robertson, Prognostic Significance of the Metastasis-inducing Protein S100A4 (p9Ka) in Human Breast Cancer Cancer Research. ,vol. 60, pp. 1595- 1603 ,(2000)