Influence of Laser Parameters on Selective Retinal Photocoagulation for Macular Diseases
作者： Pradeep Gopalakrishnan
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摘要: Selective retinal photocoagulation uses short pulsed lasers to coagulate pigment epithelium selectively, while sparing the photoreceptors. The problem associated with usage of laser is difficulty in determining correct dosimetry parameters. This study quantifies influence parameters and variation thickness melanin concentration RPE over therapeutic range. laser-tissue interaction numerically investigated by analyzing transient temperature ocular tissues during treatment. rate process analysis for thermal injury employed estimate selective damage retina. contours Arrhenius integral value (Ω/Ωmax) presented this show both area magnitude caused various Results reveal that 2 μs pulsed-laser green wavelength Gaussian profile relatively more effective repetition frequency 100 Hz selectively damages RPE, 1000 produces neural retina choroid located within μm from interface. However, Ωmax orders (~ 2000 times) greater than for100 Hz. amount threshold energy required 14 thick ~25% less 10 6 requires ~35% energy.
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