DIFFERENTIATION BETWEEN NEONATAL HEPATITIS AND BILIARY ATRESIA BY MEASURING SERUM-ALPHA-FETOPROTEIN
作者： PaulM. Zeltzer , EricW. Fonkalsrud , RobertC. Neerhout , E.Richard Stiehm
DOI: 10.1016/S0140-6736(74)93146-8
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摘要: Abstract Using a qualitative Ouchterlony double-diffusion procedure with specific antiserum, α-fetoprotein (A.F.P.) was detected in the serum of ten eleven infants neonatal hepatitis, and absent seven eight biliary atresia. These differences were confirmed by quantitative radial diffusion immunoassay, which peak levels A.F.P. hepatitis significantly higher than An concentration 4.0 mg. per 100 ml. (the approximate sensitivity procedure) or greater regularly associated hepatitis. concentrations remained high throughout course reaching slightly later serum-bilirubin serum-transaminase. It is postulated that compensatory response to liver parenchyma proliferation, retrodifferentiation, renewal synthesis. By contrast, atresia proliferation tissue incapable
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