Patient report of herpes zoster pain: Incremental benefits of zoster vaccine live.

摘要: INTRODUCTION Pain following herpes zoster (HZ) can persist for months and negatively impact quality of life. To evaluate the effect vaccine live (ZVL) on progression pain HZ, we conducted a prospective cohort study HZ cases at Kaiser Permanente Southern California. METHODS ZVL vaccinated unvaccinated members aged ≥60 years with laboratory-confirmed from January 18, 2012 to February 26, 2015 were followed up within 5 days diagnosis, 30, 60, 90 days after diagnosis. was assessed Zoster Brief Inventory (ZBPI) 0-10 scale, using cut-points ≥3, ≥5, ≥7, postherpetic neuralgia (PHN) defined as ≥3 90 days. Log binomial regression used estimate adjusted risk ratios (aRRs) 95% confidence intervals (CIs) associated pain, comparing versus patients. RESULTS We interviewed 509 significantly lower risks HZ-related all time-points. The PHN in patients, respectively, 9.2% 15.4% (aRR = 0.594, CI: 0.413, 0.854); 2.0% 4.8% these patients reported ≥7 (aRR = 0.332, 0.153, 0.721). Irrespective vaccination, adults <70 years those ≥70 years similar or females males. CONCLUSION laboratory confirmation patient survey show that aside preventing reduced prevented among recipients who experienced HZ. Observational studies will be needed long-term effectiveness new recombinant its benefits protecting against PHN.