Management of primary hepatopancreatobiliary small cell carcinoma.

摘要: Background and Objectives Primary small cell carcinomas (SCC) of the pancreas, liver, gallbladder, bile ducts have only been described in case reports. We hypothesized that surgical treatment was associated with improved overall survival (OS) for patients localized hepatopancreatobiliary SCC. Methods The Surveillance, Epidemiology, End-Results (SEER) database queried SCC from 1998 to 2008. Survival analyzed Cox proportional hazards models. Results Eighty-five had nonmetastatic operative data. Hepatic a 2 month median OS, no patient underwent surgery. Stage-adjusted OS pancreatobiliary undergoing resection (19 months, 95% confidence interval [CI]: 10–42 months) greater than those who were not resected (8 CI: 4–12 P = 0.0052). Both (hazard ratio [HR]: 0.42, 0.29–0.63, P < 0.001) administration radiation therapy (HR: 0.50, 0.35–0.71, independently predicted prolonged adjusted models. Conclusion Surgical pancreatic, biliary primaries. While we recognize several biases inherent population-based study, these results provide insight into can be achieved specific locations. J. Surg. Oncol. 2013;107:692–695. © 2012 Wiley Periodicals, Inc.