Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues.
作者： Sonia Podvin , Richard Bundey , Thomas Toneff , Michael Ziegler , Vivian Hook
DOI: 10.1016/J.MCN.2015.06.008
关键词:
摘要: Abstract The goal of this study was to define profiles secreted neuropeptide and catecholamine neurotransmitters that undergo co-release from sympathoadrenal chromaffin cells upon stimulation by distinct secretagogues. Chromaffin the adrenal medulla participate in dynamic responses stress, especially ‘fight flight’, and, thus, analyses multiple is necessary gain knowledge how stress response regulates cell–cell communication among physiological systems. Results demonstrated six different secretagogues stimulated neuropeptides Met-enkephalin, galanin, NPY, VIP with catecholamines dopamine, norepinephrine, epinephrine. Importantly, quantitative showed similarities differences evaluated, composed KCl depolarization, nicotine, carbachol, PACAP, bradykinin, histamine. rank-orders were generally similar these secretagogues, but amounts each neurotransmitter occurred Epinephrine highest level secretion. (Met)enkephalin largest levels secretion compared other examined. Levels greater than neuropeptides. These data support hypothesis show results illustrate concerted nervous system.
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