Lymphocytes transformed by Epstein-Barr virus. Induction of nuclear antigen reactive with antibody in rheumatoid arthritis.

摘要: Sera from approximately two-thirds of patients with rheumatoid arthritis contain an antibody which is reactive a nuclear antigen present in human B-lymphocyte tissue culture cells. The immunological reaction can be demonstrated by precipitation and immunofluorescence. Evidence that the associated Epstein-Barr (EB) virus-transformed lymphocytes. Normal peripheral blood lymphocytes did not sera, but after infection EB virus, they showed increasing amounts as cells were transformed into continuous lines. Several established simian lymphocyte cell lines known to carry viral genomes shown arthritis-associated antigen. presented suggests different previously described