Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation.

摘要: Abstract Thirty-nine patients with extremity osteogenic sarcoma and no discernible metastases were treated amputation postoperative adjuvant high-dose methotrexate leucovorin rescue. One half of the also randomized to receive bacillus Calmette-Guerin by a multiple-puncture technique. Results have been analyzed minimum followup 10 months median 27 months. Actuarial analysis estimates that 38% current protocol remain continuously free disease for 24 compared only 17.4% historical control (P = 0.029; one-sided generalized Kruskal-Wallis test). Bacillus administered technique had effect on disease-free interval. Minor differences between regard race, age, histologic type, site size primary tumors do not affect difference in interval these two patient groups. However, somewhat lower grade lesions consideration III IV only, lessens 0.11; High-dose was virtually morbidity deaths. The small observed this study surgery plus alone point need prospective establish role treatment sarcoma.