Antibodies to plasminogen activator inhibit human tumor metastasis
作者： L. Ossowski , E. Reich
DOI: 10.1016/0092-8674(83)90093-4
关键词:
摘要: The human carcinoma HEp3 grows on the chorioallantoic membrane and metastasizes to chicken embryo with kinetics that are quantitatively predictable. We have used this experimental system test whether plasminogen activator produced by tumor is required for metastasis. Rabbit antibodies were raised against urinary urokinase; these cross-reacted blocked catalytic activity of HEp3-PA but did not inhibit PA. When administered intravenously embryos had received an inoculum cells, anti-urokinase growth at site primary inoculation membrane, they either prevented or strongly inhibited metastasis lung. Antibody treatment delayed onset pulmonary metastasis, indicating during early stages process.
elsevier.com
sci-hub.se 参考文章(33)
Hiroshi Takita, Sarah M. Camiolo, Gabor Markus, James G. Corasanti, Grant H. Hobika, John L. Evers, Content and characterization of plasminogen activators in human lung tumors and normal lung tissue. Cancer Research. ,vol. 40, pp. 841- 848 ,(1980)
Jay Unkeless, Keld Danø, Geoffrey M. Kellerman, E. Reich, Fibrinolysis associated with oncogenic transformation. Partial purification and characterization of the cell factor, a plasminogen activator. Journal of Biological Chemistry. ,vol. 249, pp. 4295- 4305 ,(1974) , 10.1016/S0021-9258(19)42516-7
T C Wun, L Ossowski, E Reich, A proenzyme form of human urokinase. Journal of Biological Chemistry. ,vol. 257, pp. 7262- 7268 ,(1982) , 10.1016/S0021-9258(18)34566-6
Irving L. Spar, Ruth L. Goodland, William F. Bale, Letitia E. Mutschler, Ralph W. Helmkamp, High specific activity iodination of gamma-globulin with iodine-131 monochloride. Cancer Research. ,vol. 20, pp. 1495- 1500 ,(1960)
Yves A. DeClerck, Peter A. Jones, Destruction of Extracellular Matrices Containing Glycoproteins, Elastin, and Collagen by Metastatic Human Tumor Cells Cancer Research. ,vol. 40, pp. 3222- 3227 ,(1980)
Judith M. Madeja, Sarah M. Camiolo, Sarah L. Schneider, Gabor Markus, Grant H. Hobika, Jashbhai Patel, John L. Evers, Plasminogen Activator Activity and Composition in Human Breast Cancer Cancer Research. ,vol. 42, pp. 219- 226 ,(1982)
Helene Wallace Toolan, Transplantable human neoplasms maintained in cortisone-treated laboratory animals: H.S. No. 1; H.Ep. No. 1; H.Ep. No. 2; H.Ep. No. 3; and H.Emb.Rh. No. 1. Cancer Research. ,vol. 14, pp. 660- 666 ,(1954)
G. Sava, M. Kopitar, T. Giraldi, Antimetastatic effects of a leukocyte intracellular inhibitor of neutral proteases. Cancer Research. ,vol. 37, pp. 3834- 3835 ,(1977)
C. P. Dagg, Jacqueline Roddy, David A. Karnofsky, Growth of transplantable human tumors in the chick embryo and hatched chick. Cancer Research. ,vol. 16, pp. 589- 594 ,(1956)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)