Role of the NO-cGMP pathway in the systemic antinociceptive effect of clonidine in rats and mice.
作者： Roberto Soares de Moura , Anna Amélia S Rios , Edmar J.A Santos , Ana Beatriz Amorim Nascimento , Ângela de Castro Resende
DOI: 10.1016/J.PBB.2004.03.011
关键词:
摘要: Abstract The mechanism underlying the analgesic effect of clonidine, an α 2 -adrenoceptor agonist, remains uncertain. Activation induces release nitric oxide (NO) from endothelial cells, which has led us to test hypothesis that observed antinociceptive induced by systemic administration clonidine depends on NO-cGMP pathway. possible involvement opioid link in was also evaluated. (intravenous or intraperitoneal) evaluated using rat paw formalin, mice tail-flick and writhing tests. Clonidine (3–120 μg/kg) a dose-dependent dose had no sedative assessed rota rod test, significantly reduced NO-synthase guanylyl cyclase inhibition. morphine, but not inhibited naloxone. Our current results suggest does involve receptor is modulated
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